It is easy to contravene the prohibition against individually attacking references used in an obviousness combination. This post dissects the issues and proposes a few ways to reduce the ability of the USPTO to simply dismiss your arguments.
The Illusion of Quality at the USPTO - its clear from the USPTO’s very own explanation of the program.
The PTAB confirms in a Honda appeal that system diagnostic inventions do not need to perform an action in response to the diagnostic determination to be patent eligible.