A recent Federal Circuit case on negative limitations provides some ammunition for applicants having trouble with written description rejections at the USPTO, especially when citing MPEP § 2173.05.
Patent Applicant Overcomes Rejection Ignoring "Configured to" Limitation
Caution: Paraphrasing Claim Elements in Arguments
E-Issuance of Patents
Drafting the Specification with Alternatives
Pie Dough Invention Burned By PTAB Interpretation of "Impact Mixing"
Breaking Down Improper Logic
All Too Easy To Miss - BRI
Machine Translations in Patent Prosecution
Hindsight - Improper or not?
Technical Expertise - Necessary But Not Sufficient
It is important to not only understand the technical advantages and improvements offered by an invention, but also to consider how claim terms may be interpreted (overly) broadly by the USPTO. Extra description at various levels of abstraction can create amendment opportunities that can help when unexpected interpretations and/or prior art are applied by the examiner.